LEP and obesity due to melanocortin 4 receptor deficiency: Nevertheless, a study in SOD1G93A mice has suggested that leptin reduction or loss is beneficial and slows disease progression [10], while other studies have investigated the potential therapeutic impact of HFD consumption, which induces obesity and increases leptin levels, in mutant SOD1 mice [18,19,20,21] and report beneficial effects in terms of survival and improved motor behavior.