Indeed, studies indicate that leptin is strongly involved in the central nervous system (CNS) [5,6] and neurological disorders [7,8,9] through mechanisms of action involving its four major signal transduction pathways, Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT), extracellular signal-regulated kinase pathway (ERK), phosphatidylinositol 3-kinase (PI3K)/Akt, and mitogen-activated protein kinase (MAPK)/sirtuin 1 (SIRT1), downstream of Ob-Rb receptors (King et al. 2018; Zhang and Chua, 2018). This evidence concerns the gene SIRT1 and nervous system disorder.