Eight of the 21 genes (i.e., ANKH, EFEMP1, GMDS, HLA-DQA1, MAFB, PRSS23, RPLP2, and TES) had been differentially expressed in POAG-affected TM tissue or SC cells (Figure 2, Table 1 and Table 2). The gene discussed is ANKH; the disease is open-angle glaucoma.