There were eight genes that were upregulated (i.e., AFAP1, COL4A1, CPXM1, ETS1, PRKAG2, PTPN1, SH2B3, and TES), and nine that were downregulated (i.e., ANGPTL2, ANTXR1, HHEX, LTBP2, MAFB, ME3, NR1H3, PCSK5, and PRSS23) in POAG-affected SC cells (Table 2). The gene discussed is ME3; the disease is open-angle glaucoma.