PCSK5 and open-angle glaucoma: There were eight genes that were upregulated (i.e., AFAP1, COL4A1, CPXM1, ETS1, PRKAG2, PTPN1, SH2B3, and TES), and nine that were downregulated (i.e., ANGPTL2, ANTXR1, HHEX, LTBP2, MAFB, ME3, NR1H3, PCSK5, and PRSS23) in POAG-affected SC cells (Table 2).