E6-stimulated OGT ubiquitination and degradation may help to counteract the antiviral activity of OGT that has been identified as a part of the host defense mechanism against viral infection by hepatitis B virus (HBV), Kaposi’s sarcoma-associated herpesvirus (KSHV), respiratory syncytial virus (RSV), and human immunodeficiency virus (HIV-1) [40,41,42,43,44,45]. This evidence concerns the gene OGT and viral infectious disease.