Aromatic amino-acids are involved in IH1/NBD1 contacts, among which F629 in the NBD1 E-helix, which is equivalent to F508 in ABCC7-CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), affected by the most common mutation (p.Phe508del) in Cystic Fibrosis (Figure 2, left panels; Figure S3 for a further comparison of ABCA3 and CFTR). Here, CFTR is linked to cystic fibrosis.