Increased expression of APE1/Ref-1 is associated with cancer progression, angiogenesis and resistance to therapy in many cancers, including cancers of the pancreas, bladder, colon, prostate, lung, breast, liver, ovary, bone, malignant peripheral nerve-sheath tumors (MPNST), sarcomas and many more [15,17,26,36,65,66,67,68,69,70,71,72,73,74,75,76,77,78]. The gene discussed is APEX1; the disease is malignant peripheral nerve sheath tumor.