ACAT1 and neoplasm: Acetyl-CoA acetyltransferase 1 (ACAT1), a lysine-acetyltransferase, once activated, can inhibit pyruvate dehydrogenase complex (PDC) activity via the acetylation of pyruvate dehydrogenase α1 (PDHA1) and PDH phosphatase 1 (PDP1), thereby inhibiting pyruvate from entering TCA and promoting the survival of tumor cells [43].