Interestingly, cell fate determinants including the Notch inhibitor Numb, the transcription factor Prospero (Pros), pros mRNA, the translational repressor Brain Tumor (Brat), and the double-stranded RNA binding protein Staufen (Stau), as well as their adaptors Miranda (Mira) and Partner of Numb (Pon), are apically localized together with the PAR complex initially [1]. This evidence concerns the gene PROS1 and brain neoplasm.