NF2 and meningioma: Building off of findings in the 1970s showing meningiomas to be associated with a deletion of Chromosome 22q, the NF-2 on 22q12 and its inactivation was later identified as a major driver of meningioma oncogenesis as well as the genetic alteration underlying the familial syndrome of neurofibromatosis type 2 [11,12,14,15,25,26].