Thanks to whole-genome sequencing technology powering the effort to further investigate the genetic underpinning of meningiomas, non-NF-2 genetic subtypes have since been identified, such as Tumor necrosis factor receptor-associated factor 7 (TRAF7), Kruppel-like factor 4 (KLF4), Smoothened, frizzled class G protein-coupled receptor (SMO), v-Akt murine thymoma viral oncogene homolog 1 (ATK1), and Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha (PIK3CA) (Figure 1). The gene discussed is SMO; the disease is meningioma.