Taken together, the embryologic origin hypothesis allows for conceptualizing the multitude of meningioma histologies and genetic biomarkers into two general subtypes: an NF-2/22q deletion family, comprising tumors originating from the neural crest with more potential to develop atypical features, and a non-NF-2 family originating from paraxial mesoderm that are generally benign and of the meningothelial variety. The gene discussed is NF2; the disease is meningioma.