In addition to genetic disorders of the mitophagy pathway in a number of neurodegenerative diseases, including Alzheimer’s disease, the role of accumulation of damaged mitochondria in neurons is emphasized, as well as mitophagy disorders resulting from the interaction of components of the mitophagy pathway, for example, Drp1, with the accumulation pathological proteins, such as synuclein, tau protein, and beta-amyloid, in neurons [21,22,23]. The gene discussed is MAPT; the disease is Alzheimer disease.