LEP and obesity due to melanocortin 4 receptor deficiency: The leptin-deficient animal model (ob/ob mice) was selected for the study because it presents a more severe phenotype than diet-induced obese (DIO) mice and rats, with more extreme obesity and inflammation as well as higher basal glycemia and insulinemia; the authors demonstrated that the peripheral administration of oxytocin reduced the infiltration of adipose tissue by macrophages in ob/ob mice and such effect was accompanied by decreased body weight gain, thus suggesting a potential beneficial role of oxytocin in the treatment of alterations typical of obesity [113].