Mutations in AIPL1 cause Leber congenital amaurosis type 4 (LCA4), and in order to recapitulate the disease phenotype in vitro, Lukovic et al. generated hiPSCs and retinal organoids from an LCA4 patient with a Cys89Arg mutation in AIPL1. The gene discussed is AIPL1; the disease is Leber congenital amaurosis 4.