SNCA and Parkinson disease: Since C. elegans does not have the structure of a mammalian brain, and SH-SY5Y cells are not true DA neurons, in follow-up studies, we will use a unilateral 6-OHDA lesion mouse model, human A53T α-synuclein-overexpressing transgenic mice, and DA neurons derived from iPS cells of PD patient to further evaluate the effectiveness of PMN, especially in terms of pharmacokinetics.