Furthermore, a rat model of human autosomal dominant lateral temporal lobe epilepsy (ADLTE), carrying a mutation (L385R) in the leucine-richglioma-inactivated 1 (Lgi1) gene, shows reduced expression of astrocytic Kir4.1 channels in the cerebral cortex and limbic regions (i.e., hippocampus and amygdala) [51], whereas Noda epileptic rats (NER), a hereditary epilepsy model exhibiting spontaneous GTCS, are characterized by a region-specific reduction in Kir4.1 of the amygdala, specifically in the astrocyte perisynaptic processes surrounding neurons [52]. Here, LGI1 is linked to autosomal dominant epilepsy with auditory features.