KCNJ10 and major depressive disorder: Although information relating to pathophysiological alterations in Kir4.1 channels of human patients is still limited, the findings of a recent study [40] have indicated that the level of Kir4.1 expression was significantly higher in the parietal cortex of MDD patients than in a control group, thereby providing evidence in support of the pathogenic role of Kir4.1 channels in MDD.