KCNJ10 and Ataxia: Loss-of-function mutations in the KCNJ10 gene have been found to elicit “EAST” (epilepsy, ataxia, sensorineural deafness, and tubulopathy) [55] or “SeSAME” (seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance) [56] syndrome.