Other studies have shown early driver mutations in epigenetic modifiers can have co-mutation with spliceosomes genes, e.g., mutation of IDH2, EZH2 can couple with mutations of SF3B1, U2AF1, RUNX1, and STAG2, to dictate disease evolution with distinct clinical phenotypes in MDS [62,112]. The gene discussed is IDH2; the disease is myelodysplastic syndrome.