NPM1 and anaplastic large cell lymphoma: Similarly, the oncogenic fusion tyrosine kinase, nucleophosmin/anaplastic lymphoma kinase (NPM/ALK), phosphorylates PSF on Y293, which is located near the RRM1 domain (residues 299–363) in the N-terminus and increases the ability of PSF to bind RNA in anaplastic large-cell lymphoma [53].