ENDOG and colonic neoplasm: In addition, LL-37 can induce apoptosis of colon cancer cells as well as T lymphocyte tumor cells (Jurkat cells) in a calpain-dependent manner and nuclear translocation of the pro-apoptotic factors AIF (apoptosis-inducing factor) and EndoG (endonuclease G) through overexpression of p53-dependent members of the Bcl-2 family (Bax and Bak), triggering DNA fragmentation, chromatin condensation, loss of mitochondrial membrane potential and phosphatidylserine externalization (apoptosis signals) [170,171].