In tumorigenic regulation, our findings revealed that upregulation of MALAT1 suppressed immunity via inhibition of the secretion of the IL-6 and TNF-α cytokines, suggesting reduced cellular apoptosis susceptibility within the immunosuppressive TME, thus promoting disease progression in EOC, which is a mechanism thought to result from preventing immune cell infiltration into the TME, promoting tumor cell invasion and migration [43]. The gene discussed is TNF; the disease is neoplasm.