Moreover, MALAT1-overexpressing dendritic cells (DCs) revealed fewer costimulatory molecules and selectively high inhibitory cytokine IL-10 secretion, resulting in more regulatory T cells (Tregs) with antigen-specific suppression, highlighting that the MALAT1 lncRNA is a novel tolerance regulator of immunity, which has important applications in heart transplantation and autoimmune diseases [42]. This evidence concerns the gene IL10 and autoimmune disease.