AKT1 and cancer: Consistent with most previous reports, lncRNA MALAT1-knockdown or -knockout was shown to inactivate the complexes of PI3K/Akt/mammalian targets of rapamycin (mTOR), MAPK/extracellular signal-regulated kinase (ERK), and Wnt/β-catenin signaling pathways [17,44], which significantly suppressed tumorigenicity and induced apoptosis in SKOV3 cells [45] and in other types of cancer cells, emphasizing the specific role of MALAT1 as an oncogenic lncRNA.