TNF and major depressive disorder: Lee et al. reported the improvement effect of MYP treatment in depression-like behaviors using FST, OFT, and tail suspension test (TST) in a mouse model of unpredictable chronic mild stress (UCMS), and reported that MYP affected the regulation of 5-HT, TNF-α, and IL-1β expression in the hippocampus and dorsal raphe nucleus (DRN) regions of the brain [31].