Concerning correlations of sphingolipid composition and levels of clinical parameters, besides inflammatory markers (IL-6 and CRP), the positive association of ferritin with LacCer, GM3, Cer C16, Cer C18, Cer C20, DhCer, and Sph suggested an interplay among SLs acyl chains, iron metabolism and ROS production in COVID-19 evolution [47,48]. The gene discussed is IL6; the disease is COVID-19.