NFKB1 and posterior cortical atrophy: In this study, we describe, for the first time, that MG-H1 is a novel paracrine factor specifically released from osteotropic PCa cells to reprogram human primary OB into a less-differentiate, mesenchymal-like phenotype, characterized by increased motility and expressing some prostate-specific traits, in a mechanism involving RAGE-driven ROS production and NF-kB pathway activation (Figure 13).