SCARB1 and infection: Nevertheless, this suggests a possible mechanism by which SARS-CoV-2 binding to HDL may enhance its infection of cells: due to the virus binding to HDL, the HDL binding to SR-B1, and the virus binding to ACE2, this may bring SR-B1 into proximity to ACE2 on the cellular plasma membrane, resulting in an SR-B1-mediated redistribution of cholesterol in the local environment of ACE2 in such a way as to favor viral entry.