Furthermore, small-molecule inhibitors of SR-B1-mediated lipid transfer (blockers of lipid transfer BLT-3 and BLT-4) were reported to abrogate the stimulation of HCV infectivity by human serum or HDL, suggesting that the enhancement of viral infection might be dependent on SR-B1’s lipid exchange activity [68,69]. Here, SCARB1 is linked to viral infectious disease.