On the other hand, in melanoma cells, where PrPC is mainly found as a pro-PrP isoform retaining its C-terminus instead of a GPI anchor, invasion and migration depends upon the interaction of pro-PrP with Filamin-A [88], which was shown to form a complex with pro-PrP and NOTCH1 in pancreatic cancer cells [18]. Here, PRNP is linked to familial pancreatic carcinoma.