A different, non-mutually exclusive mechanism is the positive regulation of the anti-apoptotic effector Bcl2, which may not only occur in gastric [42,54,58], breast [51] and glioma [63] cancer cells but is also a well-described pathway relaying the cell-survival physiological activity of PrPC (reviewed in [64]) and was even recently documented in the context of liver metabolism [65]. This evidence concerns the gene PRNP and central nervous system cancer.