Interestingly, in line with published data in other malignancies, three recent epigenetic studies of sinonasal tumors reported that IDH somatic mutations induce a CpG island methylator phenotype, reminiscent of IDH- mutant gliomas where pathways linking IDH to tumorigenesis have been described for the first time [20,21,38,39,40]. The gene discussed is IDH2; the disease is central nervous system cancer.