The direct molecular factors linking obesity and cancer are not fully understood, but the organ-dependent crosstalk between the adipose tissue and carcinomas via the vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), tumor necrosis factor α (TNFα), and other mechanisms are implicated [6]. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.