HAVCR2 and acute myeloid leukemia: Anti-TIM-3 antibodies are thus under study in myeloid malignancies, with preliminary results from a phase 1 trial studying sabatolimab (MBG453) with hypomethylating agents demonstrating an ORR of 41% in 34 AML patients, and an ORR of 62% in 35 MDS patients [74] (Table 1).