Inflammasome signaling in the MDS marrow is amplified by mutations in genes encoding DNA (cytosine-5) methyltransferase 3A (DNMT3A) and Ten-eleven translocation 2 (TET2), which diminish their ability to quell inflammation through increased production of interferon-α and β, and upregulation of IL-6 through epigenetic regulation in dendritic cells and macrophages [38,39]. The gene discussed is DNMT3A; the disease is myelodysplastic syndrome.