AKT1 and diffuse large B-cell lymphoma: To dig further, we found that, compared with their counterpart, group B DLBCL tumors exhibited more significantly increased activation and/or higher expression of phosphatidyl-inositol-3 kinase (PI3K) pathway-associated proteins, including PIK3CD, p-PDK1, p-AKT, p-IKK A/B, NF-κB, MYC, BCL2L1, and MCL1 (Figure 5e).