SOX2 and posterior cortical atrophy: Although progress has been made in the recent years in identifying a few molecular drivers of t-NEPC/NEPC transdifferentiation including SOX2 and N-MYC [6,7,8,9,10,11,12,13], the signaling mechanisms that foster the NEPC pathophysiology particularly in the context of the intercellular communication between PCa cells in sustaining the phenotype remains largely elusive.