SOX2 and posterior cortical atrophy: Further, consistent with the corresponding mRNA data (Figure 1K–P), the treatment of LNCaP or 22Rv1 human PCa cells with exosomes derived from TBX2DN cells (PC3TBX2DN or C4-2BTBX2DN) decreased SOX2 expression, while conversely, exosomes obtained from LNCaPTBX2 cells increased SOX2 expression when compared with the exosomes obtained from the respective Neo control cells (Figure 3B).