TBX2 and posterior cortical atrophy: To investigate the potential impact of individual EV fractions and soluble factors (SFs) derived from TBX2 modulated cells on neuroendocrine transdifferentiation, 22Rv1 and LNCaP human PCa cells were treated as depicted in Figure 1I. The efficient internalization of exosomes was confirmed by PKH67 staining and confocal microscopy (Figure 1J).