Among these markers, we observed that SOX2, MYCN, NKX2-2, and SCG3 were consistently altered with TBX2 genetic modulation (by DN and overexpression approaches) across all three human PCa cell lines used, i.e., PC3, C4-2B, and LNCaP (Figure 1A–C). Here, NKX2-2 is linked to posterior cortical atrophy.