EZH2 and neoplasm: Based on EZH2 positivity, the samples were then divided in three categories, using the median (1.5%) and the third quartile (3%) of EZH2 distribution as cut-offs: <1.5% of positive tumor cells (EZH2low); 1.5% ≤ x ≤ 3% of positive tumor cells (EZH2intermediate); and >3% of positive tumor cells (EZH2high).