TNF and ovarian neoplasm: Once formed, pro-tumoral TAMs affect the ovarian tumor microenvironment by the secretion of anti-inflammatory cytokines, such as IL-4, -5, -6, -10, as well as tumor necrosis factor α (TNF- α) and TGF-β [105], altogether impairing the activity of other immune cells in the tumor microenvironment (Figure 3).