Since ERK1/2 is also a well-known pathway involved in EMT of PDAC cells [4], our results suggest the possibility that, in this tumor context, PKCε signaling, when activated in consequence of highly expression of FGFR2c, could simultaneously repress autophagy and orchestrate the EMT program directly converging on ERK1/2 pathway. This evidence concerns the gene MAPK3 and neoplasm.