Similarly to what has been already proposed in PDAC for MEK/ERK signaling in PDAC [14], our findings can be explained considering that a negative regulation of autophagy (such as that exerted by FGR2c and by its PKCε downstream signaling) actually results in an oncogenic effect, as it can counteract tumor cell dependence on autophagy for survival. This evidence concerns the gene PRKCE and neoplasm.