PDX1 and familial pancreatic carcinoma: While mouse models such as the KrasLSL-G12D/+; Pdx1-Cre [3] and KrasLSL-G12D/+; Trp53LSL-R172H/+; and Pdx1-Cre [4] were particularly useful for studying several aspects of pancreatic cancer biology, thus far therapies evaluated primarily in these preclinical models were not translated into improved clinical outcomes for patients.