This was reminiscent of, yet in contrast to previous findings describing isoform-specific roles of PRRX1a and 1b in pancreatic cancer cells, with PRRX1b promoting HGF-mediated invasion, tumour dedifferentiation and EMT in the primary tumour, and PRRX1a driving differentiation and mesenchymal-epithelial transition at distant sites [65]. This evidence concerns the gene HGF and neoplasm.