ACTA1 and neoplasm: Further, TGFβ-R2 blockade, in the p48-Cre; LSL-KrasG12D; Cdkn2alox/lox autochthonous model of PDAC and in orthotopic models, resulted in a reduction in αSMA fibroblasts with a subsequent reduction in collagen deposition, tumour cell differentiation and reduced metastases [31].