Whether these T regs contribute to the exacerbated carcinogenesis observed in LPTENmiR21KO remains to be investigated in depth, but in this regard, infiltration of T regs and exhausted CD8+ T cells in peri-tumoral and tumoral tissues of individuals diagnosed with HCC was shown to impair anti-tumoral responses, therefore promoting disease progression and worsening the disease prognosis [126]. This evidence concerns the gene CD8A and hepatocellular carcinoma.