PTEN and cancer: Besides well-known mutations associated with HCC (e.g., TERT, TP53, MYC, WNT, CTNNB1, CCND1, PTEN, [1,2]), numerous other mechanisms are deregulated and contribute to the development and heterogeneity of HCC, including DNA methylation events, chromatin structure changes, and post-transcriptional regulation of cancer-related factors by non-coding RNAs (e.g., microRNAs (miRNAs), long non-coding RNAs), or RNA-binding proteins [4,5,6,7].