To further assess the tumor-suppressive role of miR-21 in hepatocytes, we generated mice with floxed alleles of the Pten and Mir-21a genes and expressing a Cre recombinase transgene under the control of a hepatocyte-specific albumin promoter (AlbCre), thus leading to the deletion of both PTEN and miR-21 specifically in the hepatocytes (LPTENmiR21KO mice). Here, ALB is linked to neoplasm.