STAT3 and cancer: Finally, besides Cdc25a, and consistent with the detected over-activation of STAT3 in LPTENmiR21KO mice (Figure 4D), deregulations of genes involved in inflammation/immune responses such as the selenoprotein Selp and Cxcl10 cytokine, were also observed in the livers of both HCC mouse models (Figure 5A,B) further suggesting deregulated immune responses with cancer development when miR-21 is suppressed.