DKK1 and neoplasm: Additionally, significantly different S-DKK1 levels were observed with respect to tumor stage (p = 0.047) and lymphatic vessel infiltration (p = 0.093), while no significant differences were observed for lymphatic node metastasis (p = 0.198), distant metastasis (p = 0.550), venous vessel infiltration (p = 0.108), tumor grading (p = 0.553) and resection status of the tumor margins (p = 0.542).