The progression of PanINs to PDAC can be mimicked by the pancreas-specific expression of tumor associated genes in GEMMs, the most commonly used of which is the lox-stop-lox (LSL)-KrasG12D/+; LSL-Trp53R172H/+; Pdx-1-Cre (KPC) mouse [54]. This evidence concerns the gene PDX1 and neoplasm.