KRAS and neoplasm: Sanger sequencing for KRAS or whole exome sequencing on 88 PDOs confirmed 69 (78%) of the PDOs were derived from the tumor cells, as they harbored genetic alterations consistent with PDAC; however, 19 (22%) of the PDOs arose from the outgrowth of normal cells [47], ultimately meaning that the success of growing PDAC tumor organoids is lower than the reported success of PDO generation.