RNF43 and pancreatic intraductal papillary-mucinous neoplasm: These less common premalignant tumors have distinct histological features, and molecular profiles that differ from PanIN associated PDACs, for example, GNAS and RNF43 mutations are found in IPMN, RNF43 mutations are present in mucinous cystic neoplasms, and PIK3CA and PTEN mutations are present in intraductal tubulopapillary neoplasm [13].