Both human PDAC tissue and a murine model of PDAC also revealed the existence of three cancer-associated fibroblast (CAF) subtypes [25,26,27]: inflammatory CAFs (iCAFs), activated by paracrine factors from cancer cells; myofibroblastic CAFs (myCAFs), which are dependent on juxtracrine interactions with cancer cells; and antigen presenting CAFs (apCAFs), which express genes from the antigen-presenting major histocompatibility complex (MHC) class II family [25,26,27]. This evidence concerns the gene HLA-C and cancer.