In CRC, Glutamate Ionotropic Receptor AMPA Type Subunit 4 (GRIA4), Solute Carrier Family 8 Member A1 (SLC8A1), and Synapsin III (SYN3) have a higher methylation degree in tissue, stool, and cfDNA [102]. The gene discussed is GRIA4; the disease is colorectal carcinoma.