When a panel containing mSDC2, methylated secreted frizzled-related protein 1 (mSFRP1), methylated secreted frizzled-related protein 2 (mSFRP2) and methylated proline-rich membrane anchor 1 (mPRIMA1) was investigated for detecting adenoma and CRC in plasma, a higher performance was obtained compared with each methylated gene alone [65]. Here, FRZB is linked to colorectal carcinoma.