Recent studies focused on potential biomarkers that can be used in medical practice for the early detection of CRC, which may include the above-mentioned genes or others such as UNC5D, KCNA1 [106], FMN2 [107], JAM3 [108], GSDME [109], CRF [110], SMAD3 [111], SCTR [112], CNRIP1 [113], NEUROG1 [114], and p16 [115]. The gene discussed is GSDME; the disease is colorectal carcinoma.