ST-EPNs have been recently stratified into two major groups: supratentorial ependymoma, ZFTA fusion-positive (ST-EPN-ZFTA) and supratentorial ependymoma, YAP1 fusion-positive (ST-EPN-YAP1) [9] consistently with gene expression and/or DNA methylation signatures revealed by transcriptomic methods and/or whole-genome DNA methylation profiling, respectively. This evidence concerns the gene MME and ependymoma.