PLAGL1 and central nervous system neoplasm: A distinct entity is formed by PLAGL1 rearranged EPNs, harboring EWSR1–PLAGL1 and less commonly PLAGL1–FOXO1 or PLAGL1–EP300 fusions [39], which echoes molecular landscapes of soft tissue sarcomas and a group of rare mesenchymal (non-meningothelial) and glioneuronal CNS tumors with EWSR1–non-ETS fusions [40,41].