FOXR2 and neuroepithelial neoplasm: Primitive neuroectodermal tumors of the CNS (CNS-PNETs) have been already defined as four new molecularly defined entities (CNS neuroblastoma with FOXR2 activation, CNS Ewing sarcoma family tumor with CIC alteration, CNS high-grade neuroepithelial tumor with MN1 alteration, and CNS high-grade neuroepithelial tumor with BCOR alteration) using a single multi-gene tumor-specific signature [83].