Epigenetic dysregulation of various signaling pathways, including retinoid, WNT, MAPK, TGF-β and Hedgehog signaling, and cancer-associated genes, including those encoding cadherins, matrix metalloproteinase, checkpoint regulators as well as long non-coding and microRNAs, were described in NPC (reviewed by Tsang et al. [46]). Here, TGFB1 is linked to nasopharyngeal carcinoma.