SELE and neoplasm: Thus, increased expression levels of Vascular Endothelial Growth Factor Receptor (VEGF-R), EGF-R and diverse cell adhesion molecules (e.g., Intercellular Adhesion Molecule (ICAM), Vascular Cell Adhesion Molecule (VCAM), E-selectin) as well as an increased secretion of cytokines (e.g., IL-8) are observed in activated EC or tumor associated endothelial cells (TEC).