PDCD1 and melanoma: Despite licensing for long-term use, optimal treatment duration is unknown even if some studies propose to stop the treatment for melanoma patients receiving anti-PD-1 therapy who are progression-free (confirmed by positron emission tomography (PET), coupled or not with tomodensitometry (TDM) at 12 months and with normal LDH) to avoid life-changing and life-threatening immune-mediated toxicities [17].