SOAT1 and anaplastic large cell lymphoma: Indeed, in BIA-ALCL, recurrent JAK1 and STAT3 mutations leading to activation of the JAK/STAT pathway are frequently demonstrated and STAT3 phosphorylation is uniformly demonstrated in contrast to the more heterogeneous STAT3 phosphorylation seen in ALK-negative sALCL [5,7,8,10].