In recent years, after The Cancer Genome Atlas (TCGA) Research Network findings and Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE) development, EC may be reclassified into four molecular prognostic groups: mismatch repair deficient, POLE-mutated, p53-mutated, and p53 wild-type [2]. The gene discussed is POLE; the disease is endometrial cancer.