It is well established that whereas proinflammatory cytokines such as TNF-α and IFN-γ preferentially augment Fcγ receptor (FcγR)-dependent TAM phagocytic function [27], anti-inflammatory cytokines such as Interleukin (IL)-4 and IL-13 are detrimental to FcγR-dependent uptake of cancer cells via ADCP [28]. This evidence concerns the gene FCGR2A and cancer.