Mediators released by tumor-infiltrating lymphocytes, such as T helper 2 (Th2)-cell-derived IL-4 and regulatory T (Treg) cell, and tumor-cell-derived IL-10, VEGF-A, TGF-β, and PGE2 activate an immunosuppressive program in TAMs [11,64]. The gene discussed is IL10; the disease is neoplasm.