For instance, cohorts of adenoid cystic carcinoma, esophageal carcinoma, BRCA, colon cancer, Lynch syndrome, and lung adenocarcinomas had the most significantly (p < 0.001) elevated expressions of LSM1, LSM2, LSM3, LSM4, and LSM5; while LSM7, LSM10, LSM11, LSM12, and LSM14A were significantly overexpressed in stomach adenocarcinoma and uterine corpus endometrial carcinomas compared to healthy samples (Supplementary Figure S1). The gene discussed is LSM5; the disease is Lynch syndrome.