For instance, cohorts of adenoid cystic carcinoma, esophageal carcinoma, BRCA, colon cancer, Lynch syndrome, and lung adenocarcinomas had the most significantly (p < 0.001) elevated expressions of LSM1, LSM2, LSM3, LSM4, and LSM5; while LSM7, LSM10, LSM11, LSM12, and LSM14A were significantly overexpressed in stomach adenocarcinoma and uterine corpus endometrial carcinomas compared to healthy samples (Supplementary Figure S1). Here, LSM3 is linked to Lynch syndrome.