Importantly, the observed effect of MAPK15 down-regulation on the establishment of tumor spheroids was not due to an impediment of tridimensional cell aggregation, as a significant reduction in MB cell proliferation was also observed in bidimensional monolayer cultures upon knock-down of the endogenous gene (Figure 4g,h), supporting the idea that targeted inhibition of MAPK15 activity is potentially exploitable in MB patients and may positively affect the prognosis of this disease. Here, MAPK15 is linked to neoplasm.