PDGFRA and Mobius syndrome: Conversely, although our analysis currently excludes a correlation between MAPK15 expression and clinical outcome of SHH-driven MBs (Figure S5), the role of this kinase in cilia formation and, consequently, in the activation of cilia-dependent pathways such as HH but also PDGFRα or WNT, may be more rapidly challenged, at least in preclinical studies, by using already available pharmacological inhibitors for this kinase.