UBE2M and cancer: In addition, UBE2M acts as a stress-inducible dual gene for neddylation and ubiquitylation [19] and promotes proliferation and migration in HCCs via activation of β catenin and cyclin D1 [20], along with overexpression in several cancers, including HCCs [21], H1299 lung cancer [22] and osteosarcoma [23].