Indeed, despite possessing the hallmarks of terminally differentiated PCs, venetoclax sensitive MMs retain or aberrantly reactivate aspects of the B-cell program, including BCL2 dependence, along with other specific patterns of B-cell gene expression and chromatin accessibility, and point to novel biomarkers of venetoclax sensitive MM independent of t(11;14) [19]. This evidence concerns the gene BCL2 and Miyoshi myopathy.