Cox univariate analysis indicated a significantly increased risk in terms of PFS and OS for cases with ISS stage III, 13q deletion, TP53 alterations associated with 1q gain, DIS3 mutations, t(4;14), the occurrence of 1q gain/amp, and MAF translocation, while ISS stage I and the presence of HD reduced such risks. This evidence concerns the gene TP53 and Huntington disease.