Oweida et al. showed that the immune checkpoint receptor T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), was upregulated on TIL CD8+ T cells and Treg after radiation (1 × 10 Gy) plus PD-L1 blockade in head and neck squamous cell carcinoma orthotopic tumor bearing mice (LY2 and MOC2) [48]. This evidence concerns the gene CD8A and neoplasm.