In breast (TUBO) and colon (MC38) cancer models, 1 × 12 Gy or 1 × 20 Gy increased the level of PD-L1 expression, and the combination of those regimens with an anti-PD-L1 antibody resulted in an efficient tumor control on both irradiated and non-irradiated lesions [15]. The gene discussed is CD274; the disease is cancer.