Injecting soluble sFGFR3 into mice harboring tumors with FGFR3 activating mutations neutralized FGFR ligands (FGF2, FGF9, FGF18, etc.)and rescued the symptoms of FGFR3 germline mutation, which causes achondroplasia of mice after birth [75]. Here, FGFR3 is linked to achondroplasia.