Oncogenes with at least a partially overlapping function in AML include receptor tyrosine kinase and RAS-MAPK genes (FLT3, KIT, NRAS, KRAS, etc., hereafter signaling genes) [26], TET2 and IDH1/2 [27], or TP53 and PPM1D [28]. The gene discussed is TET2; the disease is acute myeloid leukemia.